Insights into Nutrient Absorption and Gut Health
Over the past century, scientists have extensively studied the intestinal vasculature due to its crucial role in absorbing and distributing nutrients from ingested food.
This review* published in Journal of Experimental Medicine by Jeremiah Bernier-Latmani and Prof Petrova focuses on both classic and recent research regarding the molecular mechanisms governing the specific functions of blood and lymphatic vessels in the intestines.
Recent studies have unveiled new insights into how these vessels function, including their role in maintaining the health of intestinal cells, managing inflammation caused by microbiota, recruiting immune cells unique to the gut, and communicating with other organs in the body.
The review emphasizes that intestinal function is regulated at both systemic and cellular levels. For example, after eating, there is a significant increase in blood flow to the intestines to support digestion and nutrient absorption. Additionally, the presence of small openings in the endothelial cells lining the vessels is essential for absorbing nutrients.
By integrating past discoveries with new molecular insights, researchers hope to improve our understanding of intestinal function, leading to advancements in optimizing nutrient absorption, enhancing drug delivery, and treating patients.
*Mechanisms and functions of intestinal vascular specialization
by Carine Dournes Söhnlein (DO UNIL-CHUV communication)