Gfeller Lab among the SIB Remarkable Outputs 2023
Discover the SIB Remarkable Outputs 2023 - outstanding works from SIB members over the year. The 2023 edition of the Remarkable Outputs is out!
This year, seven works have been selected to represent SIB's outstanding contributions to bioinformatics. These offer a brilliant illustration of expertise and high standards in research, from exciting AI-powered resources and open science solutions to discoveries holding promise for medicine.
Among the laureates, a publication of Gfeller Lab
Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
In this study published in Immunity, a large set of ligands targeted by specific immune cells is collected and curated. Combined with advanced machine learning, it improves predictions of which potentially harmful molecules activate immune responses. This study further reveals a unique way some of these ligands bind to their receptor. These results may contribute to accelerating personalized immunotherapy approaches in autoimmune diseases or cancer.
What the committee said about the work: “This study represents a significant scientific breakthrough, as it shifts the paradigm in the understanding of MHC Class II peptides and their recognition by CD4+ T cells. It will be directly relevant in the design of therapeutic treatments for immune diseases and cancers.”
by Carine Dournes Söehnlein (DO communication)