The Gfeller Lab develops the MHC Motif Atlas to improve predictions of T-cell epitopes.
Major histocompatibility complex (MHC) molecules are responsible for presenting peptides on the cell surface for T-cell recognition. These peptides are the main targets of T cells recognizing cancer cells, whether spontaneously or after cancer immunotherapy. MHC molecules show high diversity across individuals, and different MHC bind different peptides.
Through this project*, the UNIL CHUV Department of oncology’s Gfeller Lab, also affiliated with the Swiss Institute of Bioinformatics (SIB), developed an integrated database to analyse and visualize the binding specificities of thousands of MHC molecules, as well as large collections of MHC ligands that can be used to improve predictions of T-cell epitopes.
Research for this project was supported by the Swiss Cancer Research Foundation (KFS-4961-02-2020).
*The MHC Motif Atlas: a database of MHC binding specificities and ligands.