A comprehensive analysis of existing IDO1 structural data by the SIB and the Department of oncology UNIL CHUV sheds new light on its structure and function.
The review: Structure and Plasticity of Indoleamine 2,3-Dioxygenase 1 (IDO1) is the culmination of nearly fifteen years of work led by the SIB Swiss Institute of Bioinformatics's Molecular Modeling group of Prs Vincent Zoete and Olivier Michielin, both faculty at the Department of oncology UNIL CHUV.
Currently, over fifty experimental structures of IDO1 in complex with different ligands are available in the Protein Data Bank. Dr Ute Roehrig, Senior research scientist of the SIB Molecular Modeling group, is the first author of this perspective exploiting the wealth of recent structural data to shed light on open issues regarding IDO1's structure and function. The analysis sheds new light on several open issues regarding IDO1’s structure and function.
The breadth of this research has given rise to eight publications with Dr Ute Roehrig as first-author - five of which were published in the Journal of Medicinal Chemistry.
It was conducted in close collaboration with the Department of oncology's T cell engineering group of Dr Melita Irving, part of the Hi-TIDe led by Pr George Coukos, and Pr Horst Vogel's group at EPFL.
Throughout its lifetime, the project has been supported by Atlantic Philanthropies, the Ludwig Institute for Cancer Research, the SIB Swiss Institute of Bioinformatics and the University of Lausanne.