The focus of this post-doctoral research will be on how to unleash anti-tumor immunity by restoring and/or sustaining T cell metabolic functions.
"With the support of the MOST Research Abroad program, the success of this work will lay the foundation to discover unexplored immunometabolic regulations and new treatment opportunities." says Pei-Chun Hsueh, member of the Ho Lab, part of the Ludwig Institute for Cancer Research Lausanne branch. "I am deeply honored and humbled to be a beneficiary of this program and I believe it is essential to help me becoming a seasoned researcher."
Cytotoxic T cells are crucial mediators against malignancy and display a key role in immune checkpoint blockade. While tumor microenvironment provides environmental restrictions which diminish the anti-tumor effector functions of infiltrating immune cells, new information about this process will be valuable to the understanding of how tumor cells impair anti-tumor immunity through undefined metabolic modulations. The goal is to unleash anti-tumor immunity by restoring and/or sustaining T cell metabolic functions based on the findings of this proposal.
The Postdoctoral Research Abroad Program, sponsored by Taiwan's Ministry of Science and Technology (MOST), supports Taiwanese postdoctoral researchers to conduct research at an accredited educational institute abroad. The program seeks to encourage young researchers to gain experience overseas, develop their global perspective, and strengthen international collaborations.