Giorgia Conte, Alberto Parras, Mariana Alves, Ivana Ollà, Laura De Diego‐Garcia, Edward Beamer, Razi Alalqam, Alejandro Ocampo, Raúl Mendez, David C. Henshall, José J. Lucas and Tobias Engel.
Pharmacoresistance and the lack of disease‐modifying actions of current antiseizure drugs persist as major challenges in the treatment of epilepsy. Experimental models of chemoconvulsant‐induced status epilepticus remain the models of choice to discover potential antiepileptogenic drugs, but doubts remain as to the extent to which they model human pathophysiology. The aim of the present study was to compare the molecular landscape of the intra‐amygdala kainic acid model of status epilepticus in mice with findings in resected brain tissue from patients with drug‐resistant temporal lobe epilepsy (TLE).