Sonja Giger, Larisa V. Kovtonyuk, Sebastian G. Utz, Mergim Ramosaj, Werner J. Kovacs, Emanuel Schmid, Vassilios Ioannidis, Melanie Greter, Markus G. Manz, Matthias P. Lutolf, Sebastian Jessberger, and Marlen Knobloch
Highlights
- Modulating lipid metabolism with malonyl-CoA increases murine HSPCs in vitro
- Malonyl-CoA promotes lymphoid cell fate of HSPCs in vitro and in vivo
- The myeloid bias in aged HSPCs is partially recovered with malonyl-CoA exposure
- Malonyl-CoA increases the numbers of human HSPCs in vitro