Hiran A. Prag, Anja V. Gruszczyk, Margaret M. Huang, Timothy E. Beach, Timothy Young, Laura Tronci, Efterpi Nikitopoulou, John F. Mulvey, Raimondo Ascione, Anna Hadjihambi, Michael J. Shattock, Luc Pellerin, Kourosh Saeb-Parsy, Christian Frezza, Andrew M. James, Thomas Krieg, Michael P. Murphy, and Dunja Aksentijević.
Succinate accumulates several-fold in the ischemic heart and is then rapidly oxidised
upon reperfusion, contributing to reactive oxygen species (ROS) production by mitochondria.
In addition, a significant amount of the accumulated succinate is released from the heart into
the circulation at reperfusion, potentially activating the G-protein coupled succinate receptor
(SUCNR1). However, the factors that determine the proportion of succinate oxidation or
release, and the mechanism of this release, are not known.