Dr. Karin Schäuble from Prof. Sanjiv Luther’s lab published an article in PLoS Biology describing how lymph node fibroblasts ( FRC) which act as organizers of the T cell rich zone, constitutively express high levels of the COX2 enzyme responsible for prostaglandin E2 (PGE2) synthesis. This PGE2 inhibits T cell expansion in contrast to its proinflammatory role on innate immune cells. In vivo, fibroblast-expressed COX2 is responsible for suppressing chronic T cell responses. COX inhibitors, such as Aspirin and Ibuprofen, belong to the most used drugs for dampening inflammatory reactions, in part by blocking PGE2 synthesis. These results represent the first direct in vivo evidence for a suppressive role of lymph node fibroblasts on the T cell response