Reassessing the Role of Diacylglycerols in Insulin Resistance
Sisitha U. Jayasinghe Aurel T. Tankeu Francesca Amati
Skeletal muscle (SM) insulin resistance (IR) plays an important role in the burden of obesity, particularly because it leads to glucose intolerance and type 2 diabetes. Among the mechanisms thought to link IR to obesity is the accumulation, in muscle cells, of different lipid metabolites. Diacylglycerols (DAGs) are subject of particular attention due to reported interactions with the insulin signaling cascade.
par Kristel Piermaria (DP)