In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment
Megan Chesnut , Laura S. Muñoz, Georgina Harris , Dana Freeman, Lucio Gama, Carlos A. Pardo and David Pamies.
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting
in a significant burden of morbidity and mortality. Disease models are necessary
to understand neuropathogenesis and identify potential therapeutics and vaccines.
Non-human primates have been used extensively but present major challenges.
Advances have also been made toward the development of humanized mouse
models, but these models still do not fully represent human pathophysiology. Recent
developments in stem cell technology and cell culture techniques have allowed the
development of more physiologically relevant human cell-based models.
par Kristel Piermaria (DP)