Protein pathway analysis to study development-dependent effects of acute and repeated trimethyltin (TMT) treatments in 3D rat brain cell cultures
Domitille Schvartz, Víctor González-Ruiz, Nadia Walter, Paola Antinori, Fabienne Jeanneret, David Tonoli, Julien Boccard, Marie-Gabrielle Zurich, Serge Rudaz, Florianne Monnet-Tschudi, Jenny Sandström, Jean-Charles Sanchez
• Trimethyltin is a neurotoxic compound inducing neuroinflammation and oxidative stress.
• TMT mechanism of action could vary according to 3D brain cells maturation stage.
• Proteomics and metabolomics profiling are innovating strategies to unravel TMT-related mechanisms.
• Pathways analysis highlighted the modification of vesicular trafficking.
par Kristel Piermaria (DP)